Ancient and Traditional Foods, Plants, Herbs and Spices Used in Diabetes by Rajkumar Rajendram;Victor R. Preedy;Vinood B. Patel; & Victor R. Preedy & Vinood B. Patel

Author:Rajkumar Rajendram;Victor R. Preedy;Vinood B. Patel; & Victor R. Preedy & Vinood B. Patel
Language: eng
Format: epub
Publisher: CRC Press (Unlimited)
Published: 2024-12-15T00:00:00+00:00

12.4 CONCLUSIONS

Balanites aegyptiaca fruits and seeds have potent anti-diabetic potentials in experimentally induced diabetic animals and in diabetic humans. The anti-diabetic effects may be mediated via improvements in the insulin secretory response, β cell function, and antioxidant defense system in addition to suppression of insulin resistance, oxidative stress, and inflammation.

12.5 SUMMARY POINTS

The number of patients with diabetes mellitus (DM), which is one of the most common problems challenging the physicians in 21st century, has increased rapidly worldwide.

The current treatments of type 2 DM include mainly oral anti-diabetic drugs, which have serious side effects. Therefore, search for alternative, safer, and more effective treatments for DM has been extended to natural plant-based remedies, which cause fewer adverse effects compared to modern synthetic drugs.

The fruits of Balanitis aegyptiaca, belonging to Zygophyllaceae, is used traditionally in Egyptian folkloric medicine as oral anti-diabetic treatment. The extracts of various parts of B. aegyptiaca fruits including epicarp, mesocarp and seed kernel have been applied as treatments.

B. aegyptiaca exerted antihyperglycemic, antihyperlipidemic, and insulinotropic actions associated with the reduction in oxidative stress, enhancement in the antioxidant defense system, and reduced apoptosis in pancreatic β cells. The treatment effects may be due to presence of saponins, flavonoids, and alkaloids.

In conclusion, the present chapter provides scientific evidence for the probable use of B. aegyptiaca fruit and seed extracts as anti-diabetic agents in DM.

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