Thyroid and Heart by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030368715
Publisher: Springer International Publishing

16.3.1.2 Results from Randomized Controlled Trials

Observational studies in which treated and untreated patients are compared may be hampered by “confounding by indication”. The physician may have taken the prognosis—and underlying (cardiovascular) comorbidity—of the patient into account when deciding to treat the patient. This means that the decision to start treatment is associated with the chance of certain outcomes, such as death. Evidence about the effects of treatment should therefore be obtained from well-designed randomized experiments [31], since prospective randomized studies are thought to be the ultimate proof of a causal effect and necessary to evaluate these observations [104]. Interventional trials aimed at correcting the TSH to within a normal range have revealed conflicting evidence on the cardiovascular benefits of such treatment.

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