Cannabis in Medicine by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030459680
Publisher: Springer International Publishing

Preclinical Research

Endocannabinoid reuptake inhibitors were suggested to be effective in reducing the hyperkinetic activity and attenuating the decreased inactivity in some 3-nitropropionic acid (3-NP)-lesioned HD rat models but failed to exhibit anti-hyperkinetic activity in other 3-NP-lesioned HD models and failed to protect against the death of GABAergic neurons in malonate-lesioned HD models [189–191]. The effects of anti-hyperkinesia sometimes were reversed when models were pre-treated with capsaicin, a vanilloid receptor (VR1) agonist, indicating a role for these receptors in the anti-hyperkinetic effects of endocannabinoid reuptake inhibitors [190]. VR1 agonists also displayed anti-hyperkinetic activity alone or combined with a CB1 agonist [190, 192]. The CB1 agonist alone only produced modest anti-hyperkinetic effects [190] or showed no effect on motor testing but significantly increased seizure events [193], indicating possible imbalances in excitatory/inhibitory neurotransmitter tone occurring in HD. Inhibiting the enzyme fatty acid amide hydrolase (FAAH) showed no efficacy in reducing hyperkinesia or altering the progressive deterioration of motor performance [190, 193].

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