12,000 Canaries Can't Be Wrong by John Molot

Author:John Molot
Language: eng
Format: epub
Tags: health
ISBN: 9781770905634
Publisher: ECW Press
Published: 2014-05-08T00:00:00+00:00

Overweight Canaries and Systemic Inflammation

Obesity is an environmentally linked illness and has many similarities to ME/CFS and MCS. TRPV1 receptors are involved. People who are overweight are more likely to have ME/CFS and fibromyalgia. They are more likely to have the pattern. They have central nervous system complaints of pain, fatigue, sleep disturbance, and mood disorders such as depression. They are more likely to have respiratory symptoms because of allergies and asthma, and they have gastrointestinal complaints from IBS and GERD. On a cellular level, fat cells in obese people suffer oxidative stress, mitochondrial dysfunction, and impaired mitochondria biogenesis. Exposure to outdoor particulate matter increases the oxidative stress and further reduces the number and function of mitochondria in fat cells.

As we gain weight, fat starts to influence our immune system. Fat cells release messenger cytokines to attract more immune system cells. So the fatter we are, the more they accumulate in our fat. These immune cells also release more cytokines, and together they put people in a state of systemic inflammation.

Obesity is known to be a cause of, or contributor to, many chronic diseases. One reason is that chronic systemic inflammation is a characteristic of obesity. It is important to understand that systemic inflammation is different from acute inflammation. Acute inflammation occurs immediately in response to a perceived attack because the immune system responds to the release of chemical messengers, the cytokines. The cells rush to the area to defend us from invasion or to repair damage after an injury. We have all experienced the classical signs of acute inflammation, which are redness, swelling, heat, and pain.

Systemic inflammation is different because:

it causes only a small rise in cytokines

there are no classical symptoms or signs of inflammation

it has subtle but systemic (whole-body) rather than local effects

it appears to perpetuate rather than resolve a disease.

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