Tumors of the Central Nervous System, Volume 10 by M.A. Hayat

Author:M.A. Hayat
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

The Wnt/JNK pathway was initially discovered due to its role in planar cell polarity in Drosophila. Binding of Wnt ligands such as Wnt11 and Wnt5A to the frizzled receptor leads to the recruitment of small GTPases such as RhoA and cdc42 resulting in activation of JNK or rho kinase. Wnt5A, in addition to acting as a ligand in the Wnt/JNK pathway, also stimulates the Wnt-calcium pathway resulting in intracellular calcium release and activation of protein kinase C, calmodulin kinase II and calcineurin. Whilst the Wnt-β-catenin pathway has been well established to have a pivotal role in tumorigenesis, these non-canonical pathways have been less well-defined and evidence of their role in cancer development has only relatively recently emerged (Jessen 2009).

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