The Washington Manual of Hematology and Oncology Subspecialty Consult by Cashen Amanda F. & Van Tine Brian

Author:Cashen, Amanda F. & Van Tine, Brian [Cashen, Amanda F. & Van Tine, Brian]
Language: eng
Format: epub
Published: 0101-01-01T00:00:00+00:00

Stage IVb. Metastatic esophageal cancer is incurable with a median survival of 9 months. Several chemotherapeutic agents including cisplatin, carboplatin, 5-FU, paclitaxel, docetaxel, vinorelbine, oxaliplatin, and irinotecan are commonly used.

In general, platinum-based doublets have the highest response rate and are typically used as first-line therapy.

Addition of cetuximab to platinum-based doublets can be considered in patients with epidermal growth factor receptor (EGFR)-overexpressing tumor.

Targeted therapies such as erlotinib and gefitinib as second-line monotherapy have been shown to offer some benefit to a small number of patients and can be considered for patients who cannot tolerate cytotoxic chemotherapy.

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