The Neurobiology of the Prefrontal Cortex by Passingham Richard E. Wise Steven P. & Steven P. Wise

Author:Passingham, Richard E., Wise, Steven P. & Steven P. Wise
Language: eng
Format: epub
Publisher: OUP Oxford
Published: 2012-03-12T16:00:00+00:00

Fig. 7.10 Example stimuli for the extradimensional- and intradimensional shift tasks. Each horizontally arrayed pair of compound stimuli represents a choice. The correct, rewarded choice is noted at the bottom by the +, the incorrect choice by the —. Reproduced from Dias R, Robbins TW, Roberts AC. Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset. Behavioural Neuroscience 110:872–86, © 1996, American Psychological Association.

As yet, no one has made selective lesions in macaque monkeys with these tasks, but Dias et al. (1997) have done so in common marmosets (Callithrix). They compared the effects of lesions of the ventral PF convexity and the orbital PF cortex. The pattern of corticocortical connections suggests that the former area is homologous with ventral PF cortex (areas 12/47 and 45) in macaque monkeys (Roberts et al. 2007).

Marmoset monkeys with lesions of the ventral PF convexity could learn an extradimensional shift, but only slowly compared to normal marmosets (Dias et al. 1997). However, they performed normally on an intradimensional shift. This finding provides further support for a role of the ventral PF cortex in abstract rules that guide behaviour.

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