Renal Pathophysiology by Helmut G. Rennke & Bradley M. Denker

Author:Helmut G. Rennke & Bradley M. Denker [Rennke, Helmut G. & Denker, Bradley M.]
Language: eng
Format: epub
ISBN: 9781975109592
Publisher: Wolters Kluwer Health
Published: 2019-01-13T23:00:00+00:00

Hypokalemia

Hypokalemia is most often induced by increased gastrointestinal or urinary losses, although increased entry into the cell can also occur (Table 7.4). A low-potassium diet alone generally has a relatively minor effect on the plasma potassium concentration because urinary potassium excretion can be reduced to <15 to 25 mEq/day with potassium depletion. This response is mediated in part by a direct inhibitory effect of hypokalemia both on potassium secretion in the principal cells in the collecting ducts (see Fig. 7.2) and on aldosterone release.

TABLE 7.4. Major Causes of Hypokalemia

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