Prevention and Management of Acute and Late Toxicities in Radiation Oncology by Gokhan Ozyigit & Ugur Selek

Author:Gokhan Ozyigit & Ugur Selek
Language: eng
Format: epub
ISBN: 9783030377984
Publisher: Springer International Publishing

Classic RILD

Non-classic RILD

Clinical presentation: Weight gain, fatigue and abdominal right upper quadrant pain

Clinical presentation: Total bilirubin elevation and low albumin values

Alkaline phosphatase elevation

Transaminases elevation (up to five times)

Ascites

Increase ≥2 points in Child–Pugh (CP) score

Anicteric hepatomegaly

Absence of classic features

After hepatic irradiation in these patients, hepatocellular regeneration capacity breaks down and ends up with irreversible hepatic failure [16].

The use of Child–Pugh score helps us to characterize the outcomes of patients who develop non-classic RILD. Some published have identified studies various dose thresholds for the hepatic function. The most commonly used criterion in cirrhotic patients is an increase in Child–Pugh score ≥2.

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