Practical Cardiology by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030283285
Publisher: Springer International Publishing

Vancomycin hydrocholorided

30 mg/kg per 24 h IV in 2 equally divided

4

Class IIa; Level of Evidence B

Vancomycin therapy is reasonable only for patients unable to tolerate penicillin or ceftriaxone; vancomycin dose should be adjusted to a trough concentration range of 10–15 μg/mL

IM indicates intramuscular, IV intravenous, NVE native valve infective endocarditis, and VGS viridans group streptococci. Minimum inhibitory concentration is ≤0.12 μg/mL. The subdivisions differ from Clinical and Laboratory Standards Institute-recommended break point that are used to define penicillin susceptibly

aDoses recommended are for patients with normal renal function

bData for once-daily dosing of aminoglycosides for children exist, but no data for treatment of IE exist

cOther potentially nephrotoxic drugs (eg, nonsteroidal anti-inflammatory drugs) should be used with caution in patients receiving gentamicin therapy. Although it is preferred that gentamicin (3 mg/kg) be given as a single daily dose to adult patients with endocarditis caused by viridans group streptococci, as a second option, gentamicin can be administered daily in 3 equally divided doses

dVancomycin dosages should be infused during the course of at least 1 h to reduce the risk of histamine-release “red man” syndrome

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