Patch Testing and Prick Testing by Jean-Marie Lachapelle & Howard I. Maibach

Author:Jean-Marie Lachapelle & Howard I. Maibach
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

6.2 TRUE Test System

TRUE Test, a ready-to-use patch test system, represents a more sophisticated approach in the technology of patch testing (Fig. 6.1), taking into account the parameter of optimal penetration and delivery of allergens through the skin [7]. The allergens are incorporated in hydrophilic gels. The excipients (e.g., hydroxypropyl cellulose, polyvinylpyrrolidone) are adapted to each individual allergen. The patches measure 0.81 cm2 (9-mm square), and the gel is coated on a polyester sheet. For protection against light and air, the strips are contained in airtight and opaque aluminum pouches. Upon application of TRUE Test, perspiration and transepidermal water loss quickly rehydrate the dried gel layer, thereby releasing the allergens onto the skin [7].The homogeneous distribution of allergens helps to minimize the potential for false-positive and irritant reactions.

Fig. 6.1The TRUE Test® patch test system, including panels 1.1, 2.1, and 3.1

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