Obesity and Brain Function by Liliana Letra & Raquel Seiça

Author:Liliana Letra & Raquel Seiça
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

5.4 Challenges and Strategies for Prevention and Control: Is There a Window of Opportunity to Revert Diabesity and/or Alzheimer’s Disease-Associated Brain Metabolic Alterations?

Mounting evidence shows that the accumulation of diabesity-associated deleterious effects over time ultimately causes detrimental effects in the central nervous system, and even mild forms of cognitive dysfunction can affect daily living activities (Pugazhenthi et al. 2016). Together with the aging of population, diabesity increases the risk of cognitive impairment and dementia (Katsiardanis et al. 2013). So, the maintenance of brain function and the reduction of risk of neurological disorders have become key issues for the society (Smith 2016). Importantly, cognitive deficits associated with metabolic dysregulation are amenable to change or even reversible by specific interventions (Hendrickx et al. 2005).

Next, current therapeutic approaches directed against insulin resistance, a hallmark of diabesity and AD, and strategies focused on glycemic control and weight loss will be discussed.

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