Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Agents by Akihiro Hirakawa Hiroyuki Sato Takashi Daimon & Shigeyuki Matsui

Author:Akihiro Hirakawa, Hiroyuki Sato, Takashi Daimon & Shigeyuki Matsui
Language: eng
Format: epub
Publisher: Springer Japan, Tokyo

3.2 The Bivariate Continual Reassessment Method

Braun (2002) attempted to find a regimen that is optimal, in the sense that acute graft-versus-host disease and disease progression rates are both kept near desired thresholds.

3.2.1 Modeling Toxicity and Efficacy Outcomes

For each subject i , let and be the indicators of toxicity and progression (that is no efficacy). (or ) indicates that toxicity (or progression) is observed, and (or ) indicates otherwise.

The respective probabilities of toxicity and progression, and , are associated with each dose via the equations

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