Mimicked Tissue Engineering Scaffolds for Maxillofacial and Articular Cartilage Surgery by Jirut Meesane

Author:Jirut Meesane
Language: eng
Format: epub, pdf
ISBN: 9789811978302
Publisher: Springer Nature Singapore

7.1.1 Mimicking of Degradation During Tissue Formation

To mimic the function of degradation, similar to natural tissue, scaffolds are created with two main types of degradation during tissue regeneration: (1) hydrolytic degradation and (2) degradation by enzymes [16, 17]. Hydrolytic degradation begins with water absorption of the scaffolds that leads to chain scission. Chain scission decreases the molecular weight that leads to the degradation of scaffolds (Fig. 7.1a). Degradation by enzymes occurs when the enzymes attach to the scaffolds and digest the texture of the scaffolds. The digestion of scaffolds leads to degradation (Fig. 7.1b). In the design of performance scaffolds, the rate of degradation has to fit the rate of new tissue regeneration [18].

Fig. 7.1a Mechanism of hydrolytic degradation b Mechanism of degradation by metalloproteinase enzyme

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