Inflammation and Metastasis by Yoshiro Maru
Author:Yoshiro Maru
Language: eng
Format: epub
Publisher: Springer Japan, Tokyo
ADAM12
Myofibroblasts express ADAM12 in the MMTV-PyMT tumor model and the W10 prostate cancer model. Mating with ADAM12-KO mice revealed requirement for ADAM12 in prostate cancer progression [138]. Critical substrates, such as HB-EGF, remains to be uncovered.
We have shown that ADAM12 binds, cleaves, and releases ephrin-A1 on endothelial cells into circulation. The soluble form of ephrin-A1 binds its own receptors EphA1 and EphA2 in lung endothelial cells to induce their co-endocytosis with VE-cadherin eventually leading to increased vascular permeability in the lungs, which facilitates the tumor cell entry into the lungs [139].
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