Establishing a Hematopoietic Stem Cell Transplantation Unit by Éliane Gluckman Dietger Niederwieser & Mahmoud Aljurf

Author:Éliane Gluckman, Dietger Niederwieser & Mahmoud Aljurf
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Personal History and Physical Examination

Personal history includes questions on general health, and past and current health disorders, including a past history of hematological, immunological, or malignant disease. Smoking and consumption of alcohol and substances causing addiction, as well as current medical treatments, give important information on donors’ health status and risk behavior. Family history may point to hereditary disorders that are not yet clinically apparent. Systemic history must include questions on allergies and cardiovascular, respiratory, and neurologic symptoms and histories of neck and/or back injuries and pain. Although some of these questions are more specific for one type of donation (BM vs. PBSC), it is reasonable to ask all donors all of these questions, because the decision on which type of donation will be preferred may depend on these answers. For BM donation, there should be a complete history of previous anesthesias and their course and donors should be asked whether they have a personal or family history of malignant hyperthermia. For PBSC donation, donors should be asked whether they have previous experience with apheresis donations. History should include autoimmune disorders; splenic disorders, such as traumatic or atraumatic splenic conditions, including infections (EBV, CMV, malaria); and episodes of thrombocytopenia or thromboembolic disorders.

Questions intended to improve graft safety include:Vaccination history with live vaccines (e.g., oral polio, VZV, measles-mumps-rubella [MMR], yellow fever) during the previous weeks.

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