Esophageal Cancer by Nabil F. Saba & Bassel F. El-Rayes

Author:Nabil F. Saba & Bassel F. El-Rayes
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Optical Coherence Tomography

Optical coherence tomography (OCT) is similar to ultrasound technology but uses light waves in place of sound. It creates a cross-sectional image of tissue using infrared light by penetrating up to 3 mm in depth using a catheter through a standard endoscope. OCT does not require the administration of fluorescein. The intensity of the back-scattering of light creates cross-sectional and 3-dimensional images of tissue microstructures. The images are similar to coarse black and white histopathology. OCT does not require contact with esophageal tissue and can visualize the epithelium, basement membrane and vasculature, and lamina propria. Nuclear dysplasia cannot be observed [65]. A prospective study involving 33 patients with BE demonstrated that the sensitivity and specificity of OCT for detecting dysplasia were 68 % and 82 % [66], respectively, and the diagnostic accuracy for the four endoscopists involved ranged from 56 to 98 %. Computer-aided diagnosis (CAD) algorithms can be used to increase accuracy of detection of dysplasia and metaplasia. A recent study used histology as a reference standard and developed a CAD algorithm with a sensitivity of 82 %, specificity of 74 %, and accuracy of 83 % for detecting dysplasia in BE [67]. OCT is not currently widely available [68].

A study assessing the presence of dysplasia in BE looked at 177 biopsy-correlated images to evaluate a novel dysplasia index using OCT image characteristics of IMC and HGD in BE. The sensitivity and specificity rates for diagnosing HGD/adenocarcinoma were 83 % and 75 %, respectively [69]. There was significant correlation between diagnoses of IMC/HGD by histopathology and scores for the image features including dysplasia, surface maturation, and gland architecture [69].

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.