Environmental Epigenomics in Health and Disease by Randy L Jirtle & Frederick L. Tyson

Author:Randy L Jirtle & Frederick L. Tyson
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

6.8 Closing Remarks

One could conceive that retroelements are critically involved in a “survival-for-the-fittest” battle within the mammalian genome. Under healthy conditions, the mammalian genome has the upper hand due to silencing of L1 expression in terminally differentiated, somatic cells. Conversely, under stressful conditions the uncontrolled reactivation of L1 elements can wreak havoc in the genome. Continued progress in understanding L1 biology will allow for better understanding of L1-mediated effects on gene expression, gene disruption, genome evolution, differentiation, and disease.

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