Drug Allergy by Brian A. Baldo & Nghia H. Pham

Drug Allergy by Brian A. Baldo & Nghia H. Pham

Author:Brian A. Baldo & Nghia H. Pham
Language: eng
Format: epub
Publisher: Springer New York, New York, NY


Table 6.3Inhibition of trimethoprim–IgE antibody interactions in the sera of trimethoprim-allergic patients by trimethoprim and some structurally-related compounds

Compound and structure

% Inhibition of IgE antibody binding to TMP–Sepharose with 100 nmol of compound in sera

Group 1

Group 2

Group 3

I1

I2

A1

A2

I3

I4

I5

A3

Trimethoprim

94

96

92

84

91

94

72

49

Diaveridine

76

90

97

85

92

86

3

0

3,4,5-Trimethoxycinnamic acid

87

60

84

40

50

14

10

0

3,4-Dimethoxyphenylethylamine

63

76

93

60

80

24

11

0



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