DIAGNOSTIC PATHOLOGY: Hepatobiliary and Pancreas by Lamps Laura W. & Kakar Sanjay

Author:Lamps, Laura W. & Kakar, Sanjay
Language: eng
Format: epub
ISBN: 9780323443234
Publisher: Elsevier Health Sciences
Published: 2016-11-27T16:00:00+00:00

HGDN: CD34 Stain

CD34 immunohistochemistry typically shows weak and patchy sinusoidal pattern of staining in RNs and HGDNs. The patchy staining is often more pronounced at the periphery of the dysplastic nodule.

HCC: CD34 Stain

CD34 immunohistochemistry typically shows a diffuse sinusoidal pattern of staining in HCC. This staining pattern is seen in most HCC cases but may not be observed in some early cases and is not necessary for diagnosis.

Early HCC: Stromal Invasion

This hepatocellular nodule has features of HGDN, but the infiltration of the nonneoplastic liver parenchyma at the periphery indicates this is an early HCC. Stromal invasion is key in distinguishing early HCC from HGDN.

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