Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma by Michael J. J. Murphy

Author:Michael J. J. Murphy
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Marker

Sensitivity/specificity

Also seen in

Comment

S100

Sensitivity – 97–100%; specificity – 75–87% [4]

Numerous tumors, including but not limited to those derived from nerve sheath cells, myoepithelial cells, adipocytes, chondrocytes, and Langerhans cells [5, 6]

Nuclear and cytoplasmic stain [5, 7–10]; most sensitive marker for spindle cell/desmoplastic melanomas [11–23]

HMB-45

Sensitivity – 69–93% (77–100% in primary melanomas, 56–83% in metastatic melanomas) [7, 8, 11–13, 15, 24, 25]

PEComas (angiomyolipomas, lymphangiomyomatosis, pulmonary “sugar” tumors), meningeal melanocytomas, clear cell sarcomas, some ovarian steroid cell tumors, sweat gland tumors, some breast cancers, renal cell carcinoma with a t(6;11)(p21;q12) translocation [6, 12, 26–33]

Cytoplasmic stain; decreased sensitivity in metastatic melanoma [6, 8, 10, 11, 34, 35]; can be used to help distinguish nevi from melanoma [7, 8, 12]

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