Dermatology Atlas for Skin of Color by Diane Jackson-Richards & Amit G. Pandya

Author:Diane Jackson-Richards & Amit G. Pandya
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

30.1.3 Natural History and Prognosis

In the beginning stages of SSc, soft tissue swelling and arthralgia, as opposed to skin induration, in the area of involvement are prominent. Hyperpigmentation, calcinosis cutis, and telangiectasias are skin changes that occur late in the disease course. With eventual remission, the skin softens, although pigmentary changes and hand changes tend to persist. Antibodies to topoisomerase I (Scl-70) are associated with interstitial lung disease in patients with SSc and are more frequent in African Americans [1]. African Americans experience more severe disease manifestations with increased digital ulcers, pitting, and gangrene; more extensive skin, lung, renal, and gastrointestinal involvement; and higher mortality rates [2]. In comparison, Hispanic patients have more frequent musculoskeletal signs and symptoms [4].

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