Current Diagnosis Treatment Obstetrics Gynecology, Eleventh Edition by Alan H. DeCherney Lauren Nathan T. Murphy Goodwin Neri Laufer ashley s. roman

Author:Alan H. DeCherney, Lauren Nathan, T. Murphy Goodwin, Neri Laufer, ashley s. roman
Language: eng
Format: epub
Published: 2018-10-11T16:00:00+00:00

ACUTE FATTY LIVER OF PREGNANCY

ESSENTIALS OF DIAGNOSIS

Acute fatty liver of pregnancy (AFLP) is a rare complication of the third trimester of pregnancy involving acute hepatic failure (average gestational age at onset of 36 weeks).

Symptoms of AFLP include malaise, anorexia, nausea, vomiting, epigastric pain, headache, or jaundice.

Laboratory abnormalities include thrombocytopenia, elevated transaminases, hyperuricemia, and elevated creatinine. Additionally, hyperbilirubinemia, hypoglycemia, and hyperammonemia are found.

Other findings may include hypertension, low-grade fever, bleeding from coagulopathy, agitation, or confusion of the patient.

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