Contrast-Enhanced Mammography by Marc Lobbes & Maxine S. Jochelson

Author:Marc Lobbes & Maxine S. Jochelson
Language: eng
Format: epub
ISBN: 9783030110635
Publisher: Springer International Publishing

5.4.1 Tumor Response

CEM is currently being compared to MRI in larger, ongoing prospective clinical trials for assessment of tumor response. In small pilot studies, CEM has been compared to MR in the assessment of tumor response in breast cancer patients undergoing neoadjuvant systemic therapy. Findings in preliminary studies have concluded CEM is comparable in accuracy in assessing complete response versus residual disease [23, 24]. In a study of 65 patients, equivalence tests demonstrated that mean tumor size measured by CEM (P = 0.009) or by MRI (P = 0.01) was equivalent to the mean tumor size measured by pathology within −1 and 1 cm range [24]. Larger studies with subgroup analyses by tumor molecular subtypes are warranted and ongoing. The use of CEM with neoadjuvant chemotherapy is explored in depth in another chapter.

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