Cancer Screening in Inflammatory Bowel Disease by Joseph D. Feuerstein & Adam S. Cheifetz

Author:Joseph D. Feuerstein & Adam S. Cheifetz
Language: eng
Format: epub
ISBN: 9783030153014
Publisher: Springer International Publishing

UC ulcerative colitis, CD Crohn’s disease, PSC primary sclerosing cholangitis, US ultrasound, MRI magnetic resonance, HPV human papillomavirus

Small-Bowel Cancer

Epidemiology

Small-bowel cancer is uncommon, accounting for approximately 2% of all neoplasms of the gastrointestinal tract [3, 4]. Adenocarcinoma is the most frequent subtype, but sarcomas, lymphomas, and carcinoids have all been identified in patients with ileal CD. The estimated incidence of small intestinal adenocarcinoma in CD patients is 0.3/1000 patient-years [5, 6, 7]. A population-based study from Denmark generated a relative risk of small-bowel adenocarcinoma of 60 in patients with CD, compared to the background population [8]. Diagnosis typically occurs late in the disease course, with a mean duration of 8 years of established disease before diagnosis of small intestinal adenocarcinoma [9]. With an overall prevalence in the Crohn’s disease population of ~1%, this cancer still remains an infrequent finding in absolute terms [10].

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