Biophysics and Neurophysiology of the Sixth Sense by Nima Rezaei & Amene Saghazadeh

Author:Nima Rezaei & Amene Saghazadeh
Language: eng
Format: epub
ISBN: 9783030106201
Publisher: Springer International Publishing

Conclusions

Physiological status/physical diseases have been correlated with a variety of psychological status/mental diseases. The present review was intended to indicate that such correlations exist, at least in part, due to the intertwinement of emotion-regulation processes and immune-system regulation (named immunoemotional regulatory system: IMMERS). The current knowledge corroborates that the IMMERS model fits a huge set of psychological states and/or disorders (anxiety, negative affect, positive affect, aggression, loneliness, stress, worry, well-being, social rejection, socioeconomic status, shame, perceived discrimination, addiction and alcohol withdrawal, generalized anxiety disorder, post-traumatic Stress Disorder, depression, dysregulation profile, neuropathic pain, pain catastrophizing, alexithymia, intermittent explosive disorder, and chronic fatigue syndrome).

The fact that the etiology of many mental conditions entails two complex processes, i.e., emotion regulation and immune regulation, has an important implication. It is that the value of immunoemotion regulation to humans and its potential clinical benefits should be reasonable to both the human and medical society. Under these regulations, patients try to regulate their own emotions, and physicians help them using both emotion-regulation care services and medications used to regulate immune responses. However, further investigations are required to the better understanding of IMMERS’ work, which helps us to design strategies as complementary therapies.

Chapter 9 discussed how immune regulation and emotion regulation are intriguingly involved in configuring correlation between psychological status/psychiatric disorders and physiological status/physical diseases. This section was intended to unravel the IMMERS’ work and its possible health benefits. We highlighted the role of cytokines as the most important immunological compartment of the IMMERS. However, this system is also composed of many other immune and non-immune compartments, mainly chemokines, mast cells, lymphocytes, natural killer cells, antibodies and immunoglobulins, toll-like receptors, lipopolysaccharide-binding protein, oxidative stress, microglia cells, NF-κB pathway, HPA axis, neuronal circuits, and blood-brain barrier. We concluded this review by compiling a long list of strategies (including emotional disclosure, emotion with tears, stem-cell transplantation, adequate sleep, mindfulness meditation, emotion regulation therapy, exercise programs, social housing, cognitive behavioral therapy, cognitive communication, interleukin-6, and some herbal medicines) that their mechanism of action is, at least in part, innervated by IMMERS’ work.

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