Atlas of Clinical Dermatopathology by Burg Günter; Kutzner Heinz; Kempf Werner

Atlas of Clinical Dermatopathology by Burg Günter; Kutzner Heinz; Kempf Werner

Author:Burg, Günter; Kutzner, Heinz; Kempf, Werner [Burg, Günter]
Language: eng
Format: epub
Publisher: John Wiley & Sons, Incorporated
Published: 2020-12-27T00:00:00+00:00


2.3.2 North American Blastomycosis (Blastomycosis, Chicago Disease)

Figure 2.3.2 North American Blastomycosis.

Blastomyces dermatitidis, the causative organism of North American Blastomycosis, is a dimorphic fungus that affects humans and animals. Blastomycosis is a systemic disease and usually starts with pulmonary infection via inhalation of spores that are present in moist soil or rotten wood. Hematogenous dissemination leads to infection of the skin and other organs. Primary cutaneous blastomycosis with characteristic sporotrichoid spreading is very rare and may also occur in immunocompetent healthy persons. Paracoccidioides brasiliensis and Cryptococcus neoformans are responsible for the South American and the European forms of blastomycosis, respectively.

CF: The preferential site is the face. Slowly spreading verrucous papules or plaques, showing pustules and crusts, occasionally with raised borders and central regression and necrosis are typical.

HF:

Dense inflammatory infiltrate in the dermis

Intraepidermal and dermal neutrophilic

Microabscesses, reminiscent of pemphigus vegetans or iododerma

Granulomatous infiltrate with giant cells in the dermis

Necrosis

Double‐contoured (refractile double wall) thick budding organisms (PAS or Gomori silver stain), extracellularly in the necrotic center, and within giant cells



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