Atlas of Bone Marrow Pathology by Tracy I. George & Daniel A. Arber

Author:Tracy I. George & Daniel A. Arber
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Fig. 9.34T-ALL/LBL can exhibit a “double negative” immunophenotype. This flow cytometry panel demonstrates that the lymphoblasts (aquamarine on top panel, deep green on the lower panel) express CD5, CD7, cytoplasmic CD3, TdT, and CD45. They are negative for CD2, CD4, CD8, HLA-DR, and CD34 (not shown). This immunophenotype most likely represents immature thymocytes (i.e., pre-T cells) (Table 9.5)

Fig. 9.35 Early T precursor (ETP) T-ALL/LBL has a unique immunophenotype and occurs in older patients. It is significant to recognize ETP T-ALL/LBL, as it carries a poor prognosis. By definition, blasts express CD7. They can also express CD2 and cytoplasmic CD3. The blasts can have CD4 but are negative for CD8. They characteristically express one or more of the myeloid or stem cell markers CD34, CD117, HLA-DR, CD13, CD33, CD11b, or CD65. This flow cytometry plot illustrates a typical finding in ETP T-ALL/LBL. The blasts are positive for CD7, CD2, cytoplasmic CD3, CD34, CD13, TdT, and subset HLA-DR. They are negative for surface CD3, CD4, CD8, and CD1a

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