Alzheimers Disease What If There Was a Cure (3rd Edition) The Story of Ketones by Mary T. Newport

Author:Mary T. Newport
Format: epub

Ketogenic Diet and Ketone Ester Turn on T-Cells to Help Fight COVID-19 Infection

Type 2 diabetes and obesity are major risk factors for dying from the COVID-19 infection with SARSCoV2. People hospitalized with COVID-19 often need insulin to control blood glucose and new onset of diabetes is common immediately following the infection. Karagiannis and group found that blood ketone levels were increased in people with influenza but were low in people with moderate to severe COVID-19 infection and bacterial pneumonias. Their various experiments suggested that the ketone “betahydroxybutyrate (BHB) is crucial to support mitochondrial function during viral infections.” Important components of the immune system that help clear such viral infections and eliminate infected cells include two types of T-cells, which were found to contain defective mitochondria in people and in mice with COVID-19. These T-cells were “exhausted” and “skewed toward glycolysis,” a relatively inefficient process for producing ATP. However, they found through tracer studies in mouse and human T-cell cultures that providing BHB increased the numbers of T-cells and improved the survival and functionality of the T-cells, resulting in increased production of certain cytokines needed to control infection. They also found that placing mice with severe respiratory infection from COVID-19 on a ketogenic diet or providing ketone ester in their drinking water restored T-cell metabolism and function, reduced lung damage, reduced mortality, enhanced clearance of the virus, and helped with recovery from weight loss (Karagiannis 2022).

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