While Science Sleeps by Woodrow C. Monte

Author:Woodrow C. Monte
Language: eng
Format: mobi
ISBN: 9781619147355
Publisher: Amazon
Published: 2011-12-29T23:00:00+00:00

The Details of the U-Shaped Curve Explained

Lack of ethanol in the blood exposes the human body to the danger of methanol converting to formaldehyde. Without ethanol, the human body is prey to the uncontrolled conversion of methanol into formaldehyde at a number of ADH sites after exposure to methanol from the civilized diet, the environment and smoking. Atheroma, the root cause of all cardiovascular disease, is born of the interaction of formaldehyde, LDL and the macrophage at just such a location within the wall of the artery. Only the constant presence of ethanol at the ADH sites can prevent all formaldehyde production and the disease it brings.

While good evidence exists that ethanol can be produced in the gut from fermentation, the supplementation of this unreliable source through the daily consumption of ethanol drink would increase the statistical probability that the concentration of ethanol in the blood might never be reduced to zero, a state which would guarantee formaldehyde production. As the amount of ethanol in the diet increases beyond some point above two drinks a day, however, the human liver begins perceiving ethanol itself as a chemical threat and it activates the cytochrome P-450 microsomal enzyme system that helps remove ethanol from the bloodstream at twice the rate as before activation.392 The activation of this powerful system in the liver can linger for months after ethanol consumption has abated. Once the P-450 system is activated, the individual is removing ethanol from the bloodstream at a rate which makes it difficult to maintain ethanol in the blood, particularly through the overnight fasting hours. This explains the greater protection afforded by two drinks or less a day, as opposed to the risk engendered as we approach five drinks a day and risk ethanol depletion by activated liver action.

It will be obvious that at some point an individual can maintain ethanol in his or her bloodstream at all times by consuming ethanol at a rate which, even with P-450 activation, exceeds the body’s ability to metabolize it. These are some of the individuals who fit into the category of exceeding six alcoholic drinks a day. This further explains the dip in death rate in the curve for the “all cardiovascular causes of death” for drinkers consuming more than six drinks a day. The revelation that was so clear to me during the autopsy of the atheroma-free arteries of the aged alcoholic validates the truth of this final consumption category.

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