The Causes and Impacts of Neglected Tropical and Zoonotic Diseases: Opportunities for Integrated Intervention Strategies by Institute of Medicine of the National Academies

Author:Institute of Medicine of the National Academies
Language: eng
Format: epub
Tags: Health and Medicine : Diseases - Other
Publisher: NATIONAL ACADEMIES PRESS
Published: 2011-05-31T00:00:00+00:00

FIGURE A9-3 Schistosoma mansoni tegument. a| A fluorescence micrograph of the tegument of an adult male Schistosoma mansoni probed with a mouse antibody raised recombinant TSP2 (red), a tetraspinin. Nuclei. Stained with 4’,6-diamidino-2-phenylindole (DAPI), are blue. b| A schematic representation of S. mansoni TSP2 in the tegument plasma membrane. Extracellular loops (ECs) are indicated, and cysteine residues are shown (the lines between them denote the disulphide bond pairing); transmembrane domains (TMs) are shown numbered from amino terminus to carboxyl terminus. c| The tegument of an S. mansoni schistosomula incubated for 7 days with S. mansoni tsp2 (left) or luciferase (control; right) double-stranded RNAs. Digitate extensions (arrows) are more abundant on the surface of the tegument incubated with tsp2 double-stranded RNAs. Mus, muscle; Som, schistosoma; Teg. Surface layer of the tegument. Part a image is reproduced, with permission, from Loukas et al., 2007 ©Elsevier. Part c image is reproduced from Tran et al. (2010).

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