The Basic Science of Oncology, Fifth Edition by Tannock Ian & Hill Richard & Bristow Robert & Harrington Lea

Author:Tannock, Ian & Hill, Richard & Bristow, Robert & Harrington, Lea
Language: eng
Format: epub
Publisher: McGraw-Hill Education
Published: 2013-09-21T16:00:00+00:00

CHAPTER 13

Heterogeneity in Cancer: The “Cancer Stem Cell” Hypothesis

Craig Gedye

* * *

13.1 Introduction: Can We Identify the Cancer Cells that Kill Patients?

13.2 Heterogeneity in Cancer

13.2.1 Stromal Heterogeneity in Cancer

13.2.2 Genetic Heterogeneity in Cancer

13.2.3 Intratumoral Epigenetic Heterogeneity

13.3 Epithelial-to-Mesenchymal Transition

13.4 Cancer Stem Cells

13.4.1 The Cancer Stem Cell Hypothesis

13.4.2 Historical Perspective of the CSC Hypothesis

13.4.3 Methods Used to Study Cancer Stem Cells

13.4.4 Cancer Stem Cells in Hematological Malignancies

13.4.5 Cancer Stem Cells in Solid Tumors

13.4.6 Criticisms of the Cancer Stem Cell Hypothesis

13.4.7 Clinical Evidence Supporting the Cancer Stem Cell Hypothesis

13.5 Targeting Cancer Stem Cells

13.5.1 Differentiation Therapy

13.5.2 Immunological Targeting of Cancer Stem Cells

13.5.3 Targeting the Cancer Stem Cell Niche

Summary

References

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