Microstructural Parcellation of the Human Cerebral Cortex by Stefan Geyer & Robert Turner

Author:Stefan Geyer & Robert Turner
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

2.Obtaining whole-brain or whole-hemisphere MRI data requires no more effort than a small sample, and importantly, orders of magnitude less effort than whole brain histology.

3.MRI is an intrinsically three dimensional technique that yields isotropic voxels.

4.MRI does not incur irreversible distortions such as the tearing and warping induced by cutting, mounting and staining in histology.

These last two points are of particular importance, as they facilitate the accurate processing of large samples, including whole hemisphere and whole brains, something that is difficult or impossible to do with histological samples in with each section has been distorted differently, and the two in-plane directions are fundamentally different than the through-plane one. This is of particular importance when looking for discontinuities in the through-plane direction, or for example when trying to track axons or fascicles through-plane. An example of the types of data that one can acquire with ex vivo MRI together with the anatomical structures that are visible in it is given in Fig. 4.6.

Fig. 4.6Image of the human medial temporal lobe (left) acquired at 7 T with 100 μm isotropic voxels (TR = 20, TE = 5, α = variable). Right: oblique slice of same specimen through layer II of EC showing the layer II islands as brighter regions. Layers in the CA fields of the hippocampus and the dentate gyrus are clearly visible

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