Medicinal Plants of the Asteraceae Family by Medicinal Plants of the Asteraceae Family

Author:Medicinal Plants of the Asteraceae Family
Language: eng
Format: epub
ISBN: 9789811960802
Publisher: Springer Nature Singapore

7.4.14 Anti-obesity Activity

Study had shown that abdominal obesity was reduced on oral administration of safflower oil to male Wister rat model, undergoing aerobic exercise, significantly compared to control (da Silva Pérez et al. 2022). This finding was in accord with previous research by Zhang et al. (2010). They found that safflower feeding ameliorated high-fat diet induced obesity by altering adipogenic gene such as Orexin, Ghrelin, and PPARα (Zhang et al. 2010). Improvement of diet-induced obesity and blood lipid profile was also observed by Crescenzo et al. (2015) on rat while feeding safflower seed oil (Crescenzo et al. 2015). This finding was further supported by finding of Guo et al. (2020), showing reduction of total cholesterol and triglyceride in serum and liver of rat on oil feeding (Guo et al. 2020). Increased expression of LDL receptor and 7α-hydroxylase, responsible for hepatic uptake and biliary excretion, was observed in rat by Sato et al. (2000), indicating potential of safflower oil in alleviating exogenous hypocholesteremia (Sato et al. 2000). Several studies on evaluation of safflower yellow showed anti-obesity effect on high-fat diet-fed mice by improving liver functions, glucose metabolism, insulin sensitivity, peripheral leptin resistance, and increased PPARγ activity (Yan et al. 2020a, b; Lyu et al. 2022). Defatted seed extract of safflower also inhibited adipogenesis in 3 T3-L1 preadipocyte and improved lipid profile in high fat diet fed C57BL/6 J mice model (Hwang et al. 2016). This finding was further supported by study that safflower seed extract reduced lipid deposition in 3 T3-L1 adipocyte significantly compared to control (Yu et al. 2013). A dihydrophasic acid glycoside with strong antiadipogenic activity was isolated from florets of this plant, showing potential of this plant for novel antiadipogenic agent (Baek et al. 2020a). Studies on hydroxysafflower A had proved its effectiveness as anti-obesity agents in mice and rats. This activity was shown mainly as a result of improved function of digestive tract owing to change of intestinal microflora, alleviation of insulin resistance, reduced inflammation, increased expression of antioxidant enzyme in the liver, and synthesis of hormone sensitive lipase responsible for adipocyte proliferation (Adamska and Biernacka 2021).

However, some contradictory finding was also observed by Takeuchi et al showing increased fat accumulation and Santana et al. showing increased cholesterol and LDL-cholesterol in male Wister rat with metabolic syndrome (Takeuchi et al. 1995; Santana et al. 2017).

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