IschemiRs: MicroRNAs in Ischemic Stroke by Rajanikant G. K. & Pierre Gressens & Sreekala S. Nampoothiri & Gokul Surendran & Cindy Bokobza

Author:Rajanikant G. K. & Pierre Gressens & Sreekala S. Nampoothiri & Gokul Surendran & Cindy Bokobza
Language: eng
Format: epub
ISBN: 9789811547980
Publisher: Springer Singapore

6.1 Introduction

Post-ischemic angiogenesis and neurogenesis form two major endogenous adaptive responses with the potential to limit brain damage. Emerging preclinical data indicates that microRNAs (miRNAs) regulate these interwoven endogenous restorative events, particularly in the sub-acute phase of ischemic stroke, enabling functional recovery after stroke [1, 2]. The specific role of miRNAs in post-ischemic angiogenesis and neurogenesis has been established by studying the effect of (1) the mutation of Dicer, an enzyme necessary for the maturation of miRNAs and (2) the modulation of individual miRNAs that fine-tune the post-transcriptional expression of angiogenic and neurotrophic factors. This chapter elaborates on the miRNA-mediated regulation of different stages of post-ischemic neuro- and angiogenesis that potentially favor long-term recovery against ischemic stroke.

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