Immunology: An Illustrated Outline, Fifth Edition by Male David

Author:Male, David
Language: eng
Format: epub
Publisher: Garland Science
Published: 2013-07-29T16:00:00+00:00

CYTOKINE RECEPTORS

Cytokine receptors determine the responsiveness of a cell to particular cytokines. Receptors for IL-1, TNF, and the interferons are widely distributed. Others are induced on particular lineages for limited periods. For example, the high-affinity IL-2 receptor is present on antigen-activated cells for a limited period, but expression wanes if the T cell is not re-stimulated with antigen. Expression of IL-4 receptors occurs on activated B cells in an analogous fashion. Receptors for colony-stimulating factors appear during hemopoietic cell differentiation on the appropriate developing cells (see Fig. 1.11). The cytokine receptors fall into families on the basis of structural motifs and shared chains. For example, the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15 have a common signaling polypeptide (CD122), but individual cytokine-binding chains. IL-3 and IL-5 share a different chain.

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