Atlas of Cutaneous Lymphomas by Joi B. Carter Amrita Goyal & Lyn McDivitt Duncan

Author:Joi B. Carter, Amrita Goyal & Lyn McDivitt Duncan
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

10.3.2.4 Primary Cutaneous Diffuse Large Cell B Cell Lymphoma, Leg Type (DLBCL)

One of the major histopathologic characteristics of pcALCL is that the atypical cells are large and blast-like. Primary cutaneous diffuse large B-cell lymphoma has similar cytomorphology and may be included in the differential diagnosis for pcALCL. Clinically DLBCL tends to present as red to bluish nodules occurring on the lower legs; pcALCL lesions may also manifest as red-violet nodules or papules but can occur anywhere on the body. Although both DLBCL and pcALCL demonstrate large blast-like cells, they are very distinct diseases and can easily be distinguished immunohistochemically. pcALCL is composed of CD30+ neoplastic T cells, while DLBCL is defined by the presence of CD20+ B cells.

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