A Statin Nation--Damaging Millions in a Brave New Post-Health World by Dr Malcolm Kendrick

Author:Dr Malcolm Kendrick [Dr Malcolm Kendrick]
Language: eng
Format: epub
ISBN: 9781789460254
Publisher: John Blake Publishing
Published: 2018-05-19T04:00:00+00:00

One would imagine these finding may have led to a lively debate about whether the benefits of statins on CVD are due to their effect on LDL lowering, or their effect on NO synthesis. I would be happy to have this debate anywhere, with anyone. Unfortunately, it is difficult to have a debate in an empty room.

Having said this, the pleiotropic effect of statins is something that does emerge from the depths from time to time. This report entitled ‘The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes’ says: ‘Statins possess multiple beneficial effects that are independent of low-density-lipoprotein cholesterol (LDL-C) lowering and that have favorable effects on inflammation, the endothelium, and the coagulation cascade.’6

My own view is that any benefits of statins on CVD can be fully, indeed far better, explained by their beneficial impact on NO synthesis. LDL lowering is just an unfortunate adverse effect that it would be nice to remove.

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