The Metabolic Syndrome by Henning Beck-Nielsen

Author:Henning Beck-Nielsen
Language: eng
Format: epub
Publisher: Springer Vienna, Vienna

8.7 Obesity and PCOS

Studies assessing the effectiveness of metformin on weight loss in non-diabetic obese subjects and on reproductive parameters in non-diabetic PCOS are likely to have included subjects who fit the criteria of metabolic syndrome. While these studies do not allow extraction of data specific to metabolic syndrome they consistently confirm the capacity for metformin to reduce body weight or prevent weight gain in non-diabetic insulin-resistant states [20, 94]. A meta-analysis of 31 such studies (>8 weeks duration, average 1.8 years) noted that metformin reduced BMI by 5.3 %, FPG by 4.5 %, fasting insulin by 14.4 %, HOMA-IR (measure of insulin resistance) by 22.6 %, blood triglyceride by 5.3 % and LDL cholesterol by 5.6 %, with an increase in HDL cholesterol by 5.0 % compared with placebo or no treatment. This was associated with a relative reduction in the incidence of new diabetes by 40 % (absolute reduction of 6 %) [94].

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