The Long and Short Non-coding RNAs in Cancer Biology by Erwei Song

Author:Erwei Song
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

8.3.1.6 MiR-15b and MiR-16

MiR-15b and miR-16 are located in the same cluster on chromosome 3. Although the role of these two miRNAs has not been investigated in endothelial cells, they might be involved in angiogenesis. It has been shown that hypoxia represses the expression of miR-15b and miR-16 in CNE cells from human nasopharyngeal carcinoma cell line [47]. Moreover, transfection of cells with miR-15b and miR-16 results in reduced VEGF protein expression. Therefore, hypoxia-induced downregulation of miR-15b and miR-16 contributes to VEGF expression which is a fundamental regulator of normal and abnormal angiogenesis. Meanwhile, miR-15b and miR-16 can target antiapoptotic protein, Bcl-2, to induce apoptosis in leukemic cells. Thus, overexpression of miR-15b and miR-16 can be a fascinating therapeutic approach to target tumor cell death and block VEGF-mediated angiogenesis [59].

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