Sendai Virus Vector by Yoshiyuki Nagai

Author:Yoshiyuki Nagai
Language: eng
Format: epub
Publisher: Springer Japan, Tokyo

No persistence within vaccinees: the vaccine should not be able to persist within a vaccinee at sites hidden for immune surveillance or by low-level replication.

No uncontrolled genetic modifications: the vaccine should not mutate in any way in the vaccinee because mutations cannot be controlled and the outcomes cannot be foreseen.

All these requirements can be fulfilled by inactivated (killed) or replication-deficient vaccines. Optimally, these vaccine prerequisites should be combined with high efficacy and long-lasting protection based on a comprehensive immune response comprising specific humoral and cellular responses. Specifically designed vaccination platforms could then be employed for the improvement of existing vaccines but, even more importantly, for the development of novel vaccines against diseases to date unpreventable.

Another aspect of the development of such a novel class of absolutely safe and efficacious vaccines could be an increase in vaccination compliance rates. Especially in some developed countries, where overall levels of health and welfare are high, the public acceptance of vaccination is decreasing more and more. If this trend continues, the socioeconomic impact of infectious diseases will slowly increase, compromising some of the great medical achievements of the past decades and centuries. Excluding any risk through increased safety of novel vaccines will greatly contribute to attracting more people to vaccination.

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