Pathology of Challenging Melanocytic Neoplasms by Christopher R. Shea Jon A. Reed & Victor G. Prieto

Author:Christopher R. Shea, Jon A. Reed & Victor G. Prieto
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

1–2–3–4

Vertical growth phase melanoma

– Malignant melanocytes form expansile nodules, widening the papillary dermis

Loss of E-cadherin, expression of N-cadherin, αVβ3 integrin, MMP2, surviving, reduced TRPM1 (melastatin1)

– Extension into the reticular dermis/fat

– Capacity for growth in soft agar, and formation of tumor nodules when implanted in nude mice

1–2–3–4–5

Metastasis

– Malignant melanocytes grow in soft agar, and can form tumor nodules that may metastasize when implanted in nude mice

Absent TRPM1

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