Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy by Benjamin Bonavida

Author:Benjamin Bonavida
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Conclusion

Treatment with chemotherapeutic agents against colon cancer is currently limited by appearance of the therapy-resistant cancer cells. Previous studies for evaluating the molecular basis have proposed some candidates of the adjuvant therapy targets, which include P-glycoprotein, growth factors, cell membrane antigens and proteasomes. Besides them, other rationale candidates are three AKRs (AKR1B10, AKR1C1 and AKR1C3), because they are up-regulated and play roles in not only developing carcinogenesis of cells, but also acquiring colon cancer chemoresistance. Therefore, accumulation of such experimental data using the inhibitors specific to the enzymes would lead to the development of a new strategy, which makes combination of anticancer drugs and the inhibitors applicable to colon cancer chemotherapy. Since the cancer tolerance to chemotherapy is the most significant problem for other carcinomas including lung cancer, we believe that exploration of potent and specific inhibitors of the respective AKRs directly leads to the development of adjuvant drugs useful for the treatments of various kinds of cancers.

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