Circadian Rhythms and Their Impact on Aging by S. Michal Jazwinski Victoria P Belancio & Steven M Hill

Author:S. Michal Jazwinski, Victoria P Belancio & Steven M Hill
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

The proteasomal pathways are usually distinguished into two categories: the ATP-dependent and the ATP-independent pathways. It was long thought that the ATP-dependent pathway was the most important one but it was recently demonstrated that the ATP-independent pathway is also essential and even preferential under certain conditions (Erales and Coffino 2014; Pickering and Davies 2012a; Hwang et al. 2011). Indeed, in such a situation as oxidative stress, it is primordial to have a very fast response to eliminate damaged proteins and this is made possible by the ATP-independent pathway.

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