Boron-Based Compounds by Evamarie Hey-Hawkins Clara Viñas Teixidor & Clara Viñas Teixidor

Author:Evamarie Hey-Hawkins,Clara Viñas Teixidor & Clara Viñas Teixidor
Language: eng
Format: epub
ISBN: 9781119275596
Publisher: John Wiley & Sons, Inc.
Published: 2018-05-29T00:00:00+00:00

2.5.2 Boron Clusters

As mentioned in Section 2.5.1.2, one of the major limitations for BNCT to become a routine clinical practice is the need to develop drugs that are able to deposit a sufficient number of 10B atoms specifically (or preferentially) in tumor cells or tissues. In order to maximize the amount of boron in tumor cells, two strategies can be followed: (1) accumulate a high number of molecules containing just one or a few number of boron atoms each, or (2) accumulate a lower number of molecules containing a huge amount of boron atoms each. Two clear examples of these strategies are p‐BPA, which contains one boron atom per molecule (Figure 2.5.3), and sodium borocaptate, which contains 12 boron atoms per molecule (BSH; Figure 2.5.3); both currently are approved for clinical trials and used as stand‐alone BNCT drugs or in combination [42].

Figure 2.5.3 Structure of (left) sodium borocaptate (BSH), and (right) p‐boronophenylalanine (BPA).

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