B Cells in Immunity and Tolerance by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9789811535321
Publisher: Springer Singapore

8.2.3 Regulatory and Effector B Cells

With the discovery of Breg cells, B cells are now divided into effector (Beff) and regulatory subsets. Given that nearly every B-cell subset can “acquire” regulatory or effector functions, Breg and Beff cells are difficult to distinguish. Normally, cytokine expression is used to distinguish between these two groups since Breg-cell subsets predominantly produce IL-10, TGF-β, and IL-35, while Beff subsets produce IL-6, TNF-α, and IFN-γ (Matsushita 2019). The Tedder group demonstrated complex relationships between Breg and Beff cells in an EAE model (Matsushita et al. 2008). However, due to the lack of Breg-cell lineage commitment factors, it is difficult to distinguish these two B cell groups for further study of cell–cell interactions, a condition essential for future therapeutic applications.

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