The Hydrogen Bond by Aloys Hüttermann

Author:Aloys Hüttermann
Language: eng
Format: epub
Publisher: Walter de Gruyter
Published: 2019-05-15T00:00:00+00:00

As in a classic thriller, the two heroes already seem to have lost the race when Linus Pauling publishes a proposal for the structure of DNA in early 1953. But after reading this publication, they realise that the proposed structure cannot be correct. This is generally explained by the fact that Linus Pauling did not see Rosalind Franklin’s DNA X-ray images. But it still seems like there is a jinx on it. They feel like they are on the right track, but somehow it all just does not fit together.

Feel free to try what Watson and Crick did. Your task is to figure out the arrangement of the bases in DNA. The following information will help you:

– The structure of DNA is always made up of at least two DNA molecules, also called strands. The structure proposed by Linus Pauling was based on three strands. However, Watson and Crick believed that there were only two.

– Research by Erwin Chargaff had shown that the number of adenine units is equal to the number of thymine units and the number of cytosine units is equal to the number of guanine units, leading Watson and Crick to deduce that adenine and thyme as well as cytosine and guanine must somehow be connected.

– Based on Rosalind Franklin’s X-ray images and their own experiments,6 Watson and Crick assumed that the bases of DNA are positioned “on the inside”, that is, opposite each other. From this, they deduced that there must be hydrogen bonds between adenine and thymine as well as between cytosine and guanine. With adenine coming from one DNA strand and thymine from the other, the same must be true of cytosine and guanine.

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