Selenium by Dolph L. Hatfield Ulrich Schweizer Petra A. Tsuji & Vadim N. Gladyshev

Author:Dolph L. Hatfield, Ulrich Schweizer, Petra A. Tsuji & Vadim N. Gladyshev
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

26.8 Viral Infections

An observational study analyzed the prevalence of hantavirus-induced hemorrhagic fever with renal syndrome in different areas of China and found a strong association between Se deficiency and the infection rate in both rodents and humans [90]. An RCT testing high Se-yeast supplementation (200 μg/day) for 9 months in HIV-positive patients in the US reported a decrease in HIV-1 viral load and an increase in CD4 T-cell count in supplemented patients [91]. However, these patients were already receiving antiretroviral therapy (ART); thus, it remains unclear whether Se was effective alone or exhibited an effect as an adjuvant to ART. In a similar supplementation study in Botswana conducted in 878 HIV-positive patients not receiving ART (2004–2009), Se supplementation (200 μg/day) for 24 months proved to be safe and significantly reduced the risk of immune cell decline and morbidity [92]. These findings are promising (see also Chap. 28).

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