Nano-food Engineering by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030445522
Publisher: Springer International Publishing

4.1 Nanosuspension-Based Conventional Techniques

Nanosuspensions (NSs) technology is a formulation approach suitable to improve solubility and bioavailability both of hydrophilic (H) and lipophilic (L) bioactive compounds (HBACs and LBACs). A NS is a colloidal dispersion of NPs in an aqueous media, stabilized by surfactants, sometimes associated with co-surfactants, and polymers (Rabinow 2004).

NSs are gifted with high dispersibility and solubility, thanks to the very small particles dimension and the emulsified BACs gain an increased therapeutic efficacy and a reduced toxicity. NSs-based NPs are suitable for operations of pre- and post-conjugation strategy, which involve the conjugation of proper ligands, such as antibodies or others, before or after the preparation of the BACs-loaded NPs.

In such a way, a sustained, controlled and target delivery of the loaded BAC can be realized, that translates in extra stability in cells and tissues and in better therapeutic effects (Liu et al., 2010). The possible conventional approaches to prepare NSs can be grouped into two methodologies types, i.e. the top-down and bottom-up methods (Fig. 2) (Gao et al. 2011).

Fig. 2Example of the top-down and bottom-up methods to prepare NSs

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