Emotion in the Mind and Body by Maital Neta & Ingrid J. Haas

Author:Maital Neta & Ingrid J. Haas
Language: eng
Format: epub
ISBN: 9783030274733
Publisher: Springer International Publishing

In contrast, as shown in Fig. 5.3, schizophrenia may be more related to impaired goal representation and utilization mechanisms rather than to deficits in hedonic experience or initial responsiveness to reward (Barch et al., 2018; Barch, Carter, et al., 2017; Kring & Barch, 2014). Such impairments may reflect either or both altered DA function and altered activation of dorsal frontal-parietal cognitive control systems. Recent meta-analyses point to robust evidence for increased DA synthesis availability and some evidence for D2 receptor overexpression (Fusar-Poli & Meyer-Lindenberg, 2013; Howes et al., 2012), as well as replicable evidence for altered activity of cognitive control systems (Minzenberg et al., 2009). Such a framework would suggest that even though individuals with schizophrenia can experience reward and pleasure from a variety of stimuli, they may have difficulty learning appropriate reward or salience representations (Howes & Kapur, 2009) and difficulty representing and maintaining such incentive information over time so that this information can drive further action selection and motivated behavior (Barch & Dowd, 2010; Kring & Barch, 2014).

Fig. 5.3Potential pathway to motivational impairments in schizophrenia. ACC anterior cingulate cortex, BG basal ganglia, DA dopamine, DLPFC dorsolateral prefrontal cortex, OFC orbital frontal cortex. Modified with permission

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